I2E Consulting: Rat-Tissue Pathology Suite I2E Consulting, a pharma and biotech services firm, needed to reduce the heavy manual effort involved in reviewing gigapixel rat-tissue pathology slides while maintaining strict GLP and regulatory compliance.
15 Apr. 2023 / I2E Consulting
I2E Consulting supports top-10 pharma and biotech firms with data-rich toxicology assessments. Pathologists manually inspecting thousands of gigapixel NDPI tissue slides for rat studies faced massive bottlenecks: a single study could consume 250 person-hours and still miss diffuse lesions.
Steady Rabbit deployed a Core-Flex Micro-GCC squad, delivering across ten sprints over 21 weeks:
I2E Consulting – U.S.–India CRO & data-science firm
2010
Toxicology analytics, pharmacovigilance, regulatory tech
18,000 NDPI slides/year across rat & mouse studies
Reduce manual pathology effort ≥ 75 %, improve audit traceability
Slides were stored as 6–12 GB NDPI files; manual down-sampling, staining artefacts, and classic CV limitations caused slow review and low reliability. GLP auditors required provenance logs that could not be reconstructed manually. Internal DevOps capacity was tied to other LIMS upgrades, leaving no room to implement AI solutions.
Segmentation IoU 80 %; regulatory
threshold met
Slide review time 82 min → 6 min (-92 %)
Study close-out accelerated 10 weeks → 4 weeks (-6 weeks)
Working-hour saving 250 h/study; annual capacity +14 studies
Inference cost per slide USD 1.02 → USD 0.38 (-63 %)
GLP & 21 CFR Part 11 audit pass on first attempt — zero findings
SaaS productised add-on → USD 2.3M ARR forecast
Support tickets –48 %; pathologist NPS +19 points
Predictability premium (~8 % rate uplift) recouped in one study via capacity and SaaS revenue
CV & compliance SMEs parachuted in within 48 h; Buffer bench eradicated PTO risk
97 % sprint adherence across 21 weeks
Seven Plan-Left gates slashed re-work 39 % with < 2 h overhead per sprint
SageMaker lineage, Part 11 validation, spot-fleet optimisation
KPIs (IoU, time, audit pass) tied to squad incentives—no vanity metrics
Weekly demos, Slack war-room, open burn charts—zero surprises
Steady Rabbit delivered a GLP-compliant AI pipeline that cut our review time by 90 %. Auditors were impressed, clients are thrilled, and we hit every milestone without weekend heroics. Their Core-Flex model is predictability in action
